What are the effects of taking DIAMOX for altitude sickness? Will it make me sleepy/lethargic?… by

June 17, 2008 · Filed Under acetazolamide · Comment 

I'm hiking up Mt. Whitney in a week and am planning to take Diamox to avoid altitude sickness but I'm wary of side effects.


Best Answer:


Diamox
Generic name: Acetazolamide

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Why is Diamox prescribed?
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Diamox controls fluid secretion. It is used in the treatment of glaucoma (excessive pressure in the eyes), epilepsy (for both brief and unlocalized seizures), and fluid retention due to congestive heart failure or drugs. It is also used to prevent or relieve the symptoms of acute mountain sickness in climbers attempting a rapid climb and those who feel sick even though they are making a gradual climb.

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Most important fact about Diamox
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This drug is considered to be a sulfa drug because of its chemical properties. Although rare, severe reactions have been reported with sulfa drugs. If you develop a rash, bruises, sore throat, or fever contact your doctor immediately.

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How should you take Diamox?
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Take this medication exactly as prescribed by your doctor.

If you miss a dose…
Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.
Storage instructions…
Store at room temperature.

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What side effects may occur?
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Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Diamox.

Side effects may include:
Change in taste, diarrhea, increase in amount or frequency of urination, loss of appetite, nausea, ringing in the ears, tingling or pins and needles in hands or feet, vomiting

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Why should Diamox not be prescribed?
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Your doctor will not prescribe this medication for you if your sodium or potassium levels are low, or if you have kidney or liver disease, including cirrhosis.

Diamox should not be used as a long-term treatment for the type of glaucoma called chronic noncongestive angle-closure glaucoma.

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Special warnings about Diamox
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Be very careful about taking high doses of aspirin if you are also taking Diamox. Effects of this combination can range from loss of appetite, sluggishness, and rapid breathing to unresponsiveness; the combination can be fatal.

If you have emphysema or other breathing disorders, use this drug with caution.

If you are taking Diamox to help in rapid ascent of a mountain, you must still come down promptly if you show signs of severe mountain sickness.

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Possible food and drug interactions when taking Diamox
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If Diamox is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Diamox with the following:

Amitriptyline

Amphetamines such as dextroamphetamine

Aspirin

Cyclosporine

Lithium

Methenamine

Oral diabetes drugs such as glyburide

Quinidine

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Special information if you are pregnant or breastfeeding
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The effects of Diamox during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Diamox may appear in breast milk and could affect a nursing infant. If this medication is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment with Diamox is finished.

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Recommended dosage for Diamox
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ADULTS

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This medication is available in both oral and injectable form. Dosages are for the oral form only.

Glaucoma

This medication is used as an addition to regular glaucoma treatment. Dosages for open-angle glaucoma range from 250 milligrams to 1 gram per 24 hours in 2 or more smaller doses. Your doctor will supervise your dosage and watch the effect of this medication carefully if you are using it for glaucoma. In secondary glaucoma and before surgery in acute congestive (closed-angle) glaucoma, the usual dosage is 250 milligrams every 4 hours or, in some cases, 250 milligrams twice a day. Some people may take 500 milligrams to start, and then 125 or 250 milligrams every 4 hours. The injectable form of this drug is occasionally used in acute cases.

The usual dosage of Diamox Sequels (sustained-release capsules) is 1 capsule (500 milligrams) twice a day, usually in the morning and evening.

Your doctor may adjust the dosage, as needed.

Epilepsy

The daily dosage is 8 to 30 milligrams per 2.2 pounds of body weight in 2 or more doses. Typical dosage may range from 375 to 1,000 milligrams per day. Your doctor will adjust the dosage to suit your needs; Diamox can be used with other anticonvulsant medication.

Congestive Heart Failure

The usual starting dosage to reduce fluid retention in people with congestive heart failure is 250 milligrams to 375 milligrams per day or 5 milligrams per 2.2 pounds of body weight, taken in the morning. Diamox works best when it is taken every other day


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