What is the best hair loss treatment out there?… by Mt. Kilimanja
I am 43 year old male and have thinning hair on top. What is the best treatment I can buy?
Best Answer:
It is easier to prevent the aging and falling out of healthy hairs than to regrow hair in follicles that are already dormant. Finasteride (marketed in the U.S. as Propecia) and minoxidil (marketed in the U.S. as Rogaine, and some places as Regaine) have shown some success in partially reversing loss. In a one one-year study of finesteride, evaluation after one year showed five of 21 subjects (23.8%) had two-grade improvement in MNHS grade on a modified Norwood/Hamilton scale and 12 of 21 subjects (57.1%) had one-grade improvement; the others remained at the same grade.[6] However such treatments are generally ineffective at treating extreme cases of hair loss. [7]
The prospective treatment of hair multiplication/hair cloning, which extracts self-replenishing follicle stem cells, multiplies them many times over in the lab, and microinjects them into the scalp, has been shown to work in mice, and is currently under development, expected by some scientists to be available to the public in 2009-2015. Subsequent versions of the treatment are expected by some scientists to be able to cause these follicle stem cells to simply signal the surrounding hair follicles to rejuvenate.*
Topical application of ketoconazole, which is both an anti-fungal and a potent 5-alpha reductase inhibitor, is often used as a supplement to other approaches.
Interestingly, placebo treatments in studies often have reasonable success rates, though not as high as the products being tested, and even similar side-effects as the products. For example, in Finasteride (propecia) studies, the percent of patients with any drug-related sexual adverse experience was 3.8% compared with 2.0% in the placebo group.[8]
Regular aerobic exercise can help keep androgen levels naturally lower while maintaining overall health and lowering stress, though weight training may have a detrimental effect on hair by increasing testosterone levels.
Stress reduction can be helpful in slowing hair loss.
Immunosuppresants applied to the scalp have been shown to temporarily reverse hair loss, though the possibly lethal side effects of this treatment make it untenable.
Saw Palmetto (Serenoa repens) is an herbal DHT inhibitor often claimed to be cheaper and have fewer side effects than finesteride and dutasteride. Unlike other 5alpha-reductase inhibitors, Serenoa repens induces its effects without interfering with the cellular capacity to secrete PSA. [9] Saw palmetto extract has been demonstrated to inhibit both isoforms of 5-alpha-reductase unlike finesteride which only inhibits the (predominant) type 2 isoenzyme of 5-alpha-reductase. [10] [11] [12]
Polygonum Multiflorum is a traditional Chinese cure for hair loss. Whether the plant itself is useful, the general safety and quality control of herbs imported from China can be questionable.
Beta Sitosterol, which is a constituent in many seed oils, can help to treat BHP by lowering cholesterol. If used for this purpose, an extract is best. Consuming large amounts of oil to get at small quantities of beta sitosterol is likely to exacerbate male pattern baldness.
Resveratrol, from grape skins, is a lipase inhibitor. By decreasing the body's ability to absorb fat through the intestine walls, it reduces the total fat and calorie content of a person's diet.
While drastic, broad spectrum anti-androgens such as flutamide are sometimes used topically. Flutamide is potent enough to have a feminizing effect in men, including growth of the breasts.
In March 2006, Curis announced that it had received the first preclinical milestone, a $1,000,000 cash payment, in its hair growth program with Procter & Gamble Pharmaceuticals, a division of The Procter & Gamble Company. The program is focused on the potential development of a topical Hedgehog agonist for hair growth disorders, such as male pattern baldness and female hair loss.
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