Is it safe to mix the current medications?… by Victor
Currently I'm taking…
Orlistat 60 mg capsules (alli)
Women's Ultra Mega (Dietary Supplement)
Naproxen 500mg Tab
Bayer 81mg (Womens low dose + Calcium)
newly prescribed: CIPROFOLAXIN 500mg Tab (2 x day)
Don't know what to do?
Best Answer:
This is indeed a bit complicated for Yahoo! Answers. I am a physician, and the information I present to you can IN NO WAY replace your sitting down, face-to-face, with your own physician. What I am presenting herein is not to be considered medical advice, but may serve as information with which to discuss with your own, personal physician.
Here is a general breakdown of how Lexi-Interact categorises Drug-to-Drug, Drug-to-Herb and Herb-to-Herb Interactions:
Risk Rating: Action: Description
A = No Known Interaction.
Data have not demonstrated either pharmacodynamic or pharmacokinetic interactions between the specified agents.
B = No Action Needed.
Data demonstrate that the specified agents may interact with each other, but there is little to no evidence of clinical concern resulting from their concomitant use.
C = Monitor Therapy.
Data demonstrate that the specified agents may interact with each other in a clinically significant manner. The benefits of concomitant use of these two medications usually outweigh the risks. An appropriate monitoring plan should be implemented to identify potential negative effects. Dosage adjustments of one or both agents may be needed in a minority of patients.
D = Consider Therapy Modification.
Data demonstrate that the two medications may interact with each other in a clinically significant manner. A patient-specific assessment must be conducted to determine whether the benefits of concomitant therapy outweigh the risks. Specific actions must be taken in order to realize the benefits and/or minimize the toxicity resulting from concomitant use of the agents. These actions may include aggressive monitoring, empiric dosage changes, choosing alternative agents.
X = Avoid Combination.
Data demonstrate that the specified agents may interact with each other in a clinically significant manner. The risks associated with concomitant use of these agents usually outweigh the benefits. These agents are generally considered contraindicated.
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Here are how YOUR specific medications rate. I don't know what form your calcium is in, so I used Calcium Carbonate. You multivitamin was not a selectable choice, but may contain additional amounts of calcium or herbs that are not accounted for herein.
Aspirin:
[B] Calcium Carbonate (Antacids)
[D] Naproxen (NSAID (Nonselective))
Summary: NSAIDs (Nonselective) like NAPROXEN may enhance the antiplatelet effect of Salicylates (like ASPIRIN). NSAID (Nonselective) may diminish the heart protective effect of Aspirin. Aspirin may decrease the serum concentration of Naproxen. Severity Major. Reliability Rating Good.
Patient Management: Monitor for increased risk of bleeding during concomitant use of Naproxen and Aspirin. Ibuprofen, and possibly other nonselective NSAIDs, like Naproxen, may reduce the heart protective effects of aspirin. It seems prudent to avoid regular, frequent use of naproxen in patients receiving aspirin for its heart protective effects. Alternative analgesics (eg, acetaminophen) may be a safer choice. Occasional naproxen use is not likely to cause clinically significant problems. Patients may require counseling about the appropriate timing of naproxen and aspirin dosing. Naproxen should be administered 30-120 minutes after, or at least 8 hours before, aspirin.
NSAIDs (Nonselective) Interacting Members: Diflunisal; Etodolac; Fenoprofen*; Flurbiprofen*; Ibuprofen*; Indomethacin*; Ketoprofen; Ketorolac; Meclofenamate*; Mefenamic Acid; Meloxicam; Nabumetone; NAPROXEN*; Oxaprozin; Piroxicam*; Sulindac*; Tiaprofenic Acid; Tolmetin*
Calcium Carbonate:
[B] Aspirin (Salicylates)
[D] Ciprofloxacin (Quinolone Antibiotics)
[D] Ciprofloxacin (Quinolone Antibiotics)
Title: Ciprofloxaacin / Calcium Salts
Risk Rating D: Consider therapy modification
Summary: Calcium may decrease the absorption of Quinolone Antibiotics like CIPROFLOXACIN. Of concern only with oral administration of both agents. Severity Moderate. Reliability Rating Excellent.
Patient Management: Interactions can be minimized by administering oral ciprofloxacin at least 2 hours before, or 6 hours after, the dose of an oral calcium supplement. Monitor for decreased therapeutic effects of ciprofloxacin if administered with oral calcium supplements.
Quinolone Antibiotics Interacting Members: Ciprofloxacin; Gatifloxacin; Gemifloxacin; Levofloxacin; Lomefloxacin; Nalidixic Acid; Norfloxacin; Ofloxacin; Sparfloxacin; Trovafloxacin Exceptions Moxifloxacin.
Calcium Salts Interacting Members: Calcium Acetate*; Calcium Carbonate; Calcium Citrate; Calcium Glubionate; Calcium Gluconate; Calcium Lactate; Calcium Phosphate (Tribasic); Polycarbophil.
Exceptions: Calcium Chloride.
Ciprofloxacin:
[D] Calcium Carbonate (Antacids)
[D] Calcium Carbonate (Calcium Salts)
[C] Naproxen (Nonsteroidal Anti-Inflammatory Agents)
Ciprofloxacin and Calcium are discussed above. Now we will discuss Naproxen and Ciprofloxacin potential interactions.
Title: Ciprofloxacin / Naproxen
Risk Rating C: Monitor therapy
Summary: Nonsteroidal Anti-Inflammatory Agents (NSAIDs) like NAPROXEN may enhance the neuroexcitatory and/or seizure-potentiating effect of Quinolone Antibiotics like CIPROFLOXACIN. Severity Major. Reliability Rating Fair.
Patient Management: Consider the increased risk of seizure that may accompany the concomitant use of NSAIDs like NAPROXEN and quinolone antibiotics like CIPROFLOXACIN. Additional factors that may be associated with an increased risk of such an interaction include: renal dysfunction, history of seizure or other neurological disorder, and high doses/serum concentrations of either agent.
Quinolone Antibiotics Interacting Members: CIPROFLOXACIN; Gatifloxacin; Gemifloxacin; Levofloxacin; Lomefloxacin; Moxifloxacin; Nalidixic Acid; Norfloxacin; Ofloxacin; Sparfloxacin; Trovafloxacin
Nonsteroidal Anti-Inflammatory Agents (NSAIDs) Interacting Members: Celecoxib; Diclofenac; Diflunisal; Etodolac; Fenoprofen; Flurbiprofen; Ibuprofen; Indomethacin; Ketoprofen; Ketorolac; Lumiracoxib; Meclofenamate; Mefenamic Acid; Meloxicam; Nabumetone; NAPROXEN; Oxaprozin; Piroxicam; Sulindac; Tiaprofenic Acid; Tolmetin.
Naproxen:
[D] Aspirin (Salicylates)
[C] Ciprofloxacin (Quinolone Antibiotics)
Potential interactions between Naproxen and Aspirin were discussed above. We have also addressed potential interactions of Ciprofloxacin and Naproxen above.
Orlistat:
No interactions identified with others in the selection list.
Date December 30, 2007
Disclaimer: Readers are advised that decisions regarding drug therapy must be based on the independent judgment of their private clinician, changing information about a drug (e.g., as reflected in the literature and manufacturer's most current product information), and changing medical practices.
Hope this information helps.
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